Systemic lupus erythematosus, Sjögren syndromeĪ Ultrasonography and fine-needle aspiration puncture.ī Ultrasonography, mammography, and fine-needle aspiration puncture. Onset date of symptoms (days since vaccination) The remaining patient detected the adenopathy 24 days after vaccination, prompted by contact with another affected case, but she retrospectively recognised minor local symptoms in the preceding days. All lymphadenopathies had inflammatory symptoms (pain, swelling), were rounded and mobile, and all but one appeared in the first 24 h to 9 days after vaccine administration. In one patient, a mammography was also performed, with no pathological finding. In five patients, fine needle puncture aspiration was performed with results showing reactive inflammatory signs, with lymphocytic infiltrate and active germinal centres. Two of the cases had a prior history of thyroid disease (follicular adenoma and thyroid cancer), a third case was diagnosed with autoimmune thyroiditis in the course of the diagnostic work-up, and another two cases had Sjögren syndrome (one associated with hypertension and the other with systemic lupus erythematosus). None had a history of severe or unusual adverse reactions following immunisation. The lymphadenopathy appeared 7 days after the second vaccine dose and it is in resolution.Īll 20 cases were women, with ages ranging from 25 to 60 (median: 44) years ( Table). The lymphadenopathy appeared 1 day after the first vaccine dose, and it is in resolution, with significant reduction in size since onset.ī. Supraclavicular lymphadenopathy ipsilateral to the vaccination arm (left), COVID-19 vaccination, Spain, 2021Ī.
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